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　　The beginnings of molecular biology , The structure of DNA

,Genome organization： from nucleotides to chromatin, The

versatility of RNA, From gene to protein, DNA replication and

telomere maintenance, DNA repair and recombination, Recombinant DNA

technology and molecular cloning。

1 The beginnings of molecular biology

1.1 Introduction

1.2 Historical perspective

Insights into heredity from round and wrinkled peas: Mendelian

genetics

Insights into the nature of hereditary materiaL: the transforming

principle is DNA

Creativity in approach leads to the one gene-one enzyme

hypothesis

The importance of technological advances: the Hershey-Chase

experiment

A model for the structure of DNA: the DNA double helix

Chapter summary

Analytical questions

Suggestions for further reading

2 The structure of DNA

2.1 Introduction

2.2 Primary structure: the components of nucleic acids

Five-carbon sugars

Nitrogenous bases

The phosphate functional group

Nucleosides and nucteotides

2.3 Significance of 5 and 3

2.4 Nomenclature of nucleotides

2.5 The length of RNA and DNA

2.6 Secondary structure of DNA

Hydrogen bonds form between the bases

Base stacking provides chemical stability to the DNA double

helix

Structure of the Watson-Crick DNA double helix

Distinguishing between features of alternative double-helical

structures

DNA can undergo reversible strand separation

2.7 Unusual DNA secondary structures

Slipped structures

Cruciform structures

Triple helix DNA

Disease box 2.1 Friedreichs ataxia and triple helix DNA

2.8 Tertiary structure of DNA

Supercoiling of DNA

Topoisomerases relax supercoiled DNA

What is the significance of supercoiting in vivo?

Disease box 2.2 Topoisomerase-targeted anticancer drugs

Chapter summary

Analytical questions

Suggestions for further reading

3 Genome organization: from nucleotides to chromatin

3.1 Introduction

3.2 Eukaryotic genome

Chromatin structure：historical perspective

Histones

Nucleosomes

Beads-on-a-string：the 10 nm fiber

The 30 nm fiber

Loop domains

Metaphase chromosomes

Alternative chromatin structures

3.3 Bacterial genome

3.4 Plasmids

3.5 Bacteriophages and mammalian DNA viruses

Bacteriophaqes

Mammalian DNA Viruses

3.6 Organelle genomes：chloroplasts and mitochondria

Chloroplast DNA(cpDNA)

Mitochondrial DNA (mtDNA)

Disease box 3.1 Mitochondrial DNA and disease

3.7 RNA-based genomes

Eukaryotic RNA viruses

Retroviruses

Viroids

Other Subviral pathoqens

Disease box 3.2 Avian flu

Chapter summary

Analytical questions

Suggestions for further reading

4 The versatility of RNA

4.1 Introduction

4.2 Secondary structure of RNA

Secondary structure motifs in RNA

Base-paired RNA adopts an A-type double helix

RNA helices often contain noncanonical base pairs

4.3 Tertiary structure of RNA

tRNA structure：important insiqhts into RNA structural motifs

Common tertiary structure motifs in RNA

4.4 Kinetics of RNA folding

4.5 RNA is involved in a wide range of cellular processes

4.6 Historical perspective：the discovery of RNA catalysis

Tetrahymena qroUP I intron ribozyme

RNase P ribozyme

Focus box 4.1：The RNA World

4.7 Ribozymes catalyze a variety of chemical reactions

Mode of ribozyme action

Large ribozymes

Small ribozymes

Chapter summary

Analytical questions

Suggestions for further reading

5 From gene to protein

5.1 Introduction

5.2 The central dogma

5.3 The genetic code

Translating the genetic code

The 21st and 22nd genetically encoded amino acids

Role of modified nucleotides in decoding

Implications of codon bias for molecular biologists

5.4 Protein structure

Primary structure

Secondary structure

Tertiary structure

Quaternary structure

Size and complexity of proteins

Proteins contain multiple functional domains

Prediction of protein structure

5.5 Protein function

Enzymes are biological catalysts

Regulation of protein activity by post-translational

modifications

Allosteric regulation of protein activity

Cyclin-dependent kinase activation

Macromolecular assemblages

5.6 Protein folding and misfolding

MoLecular chaperones

Ubiquitin-mediated protein degradation

Protein misfolding diseases

Disease box 5.1 Prions

Chapter summary

Analytical questions

Suggestions for further reading

6 DNA replication and telomere maintenance

6.1 Introduction

6.2 Historical perspective

Insight into the mode of DNA replication: the Meselson-Stahl

experiment

Insight into the mode of DNA replication: visualization of

replicating bacterial DNA

6.3 DNA synthesis occurs from 5→3

6.4 DNA polymerases are the enzymes that catalyze DNA

synthesis

Focus box 6.1 Bacterial DNA polymerases

6.5 Semidiscontinuous DNA replication

Leading strand synthesis is continuous

Lagging strand synthesis is discontinuous

6.6 Nuclear DNA replication in eukaryotic cells

Replication factories

Histone removal at the origins of replication

Prereplication complex formation at the origins of

replication

Replication Licensing: DNA only replicates once per cell

cycle

Duplex unwinding at replication forks

RNA priming of Leading strand and Lagging strand DNA

synthesis

Polymerase switching

Elongation of Leading strands and Lagging strands

Proofreading

Maturation of nascent DNA strands

Termination

Histone deposition

Focus box 6.2 The naming of genes involved in DNA replication

Disease box 6.1 Systemic lupus erythematosus and PCNA

6.7 Replication of organelle DNA

Models for mtDNA replication

Replication of cpDNA

Disease box 6.2 RNase MRP and cartilage-hair hypoplasia

6.8 Rolling circle replication

6.9 Tetomere maintenance: the role of tetomerase in DNA

replication, aging, and cancer

Telomeres

Solution to the end replication problem

Maintenance of telomeres by telomerase

Other modes of telomere maintenance

Regulation of telomerase activity

Telomerase, aging, and cancer

Disease box 6.3 Dyskeratosis congenita: loss of telomerase

function

Chapter summary

Analytical questions

Suggestions for further reading

7 DNA repair and recombination

7.1 Introduction

7.2 Types of mutations and their phenotypic consequences

Transitions and transversions can lead to silent, missense, or

nonsense mutations

Insertions or deletions can cause frameshift mutations

Expansion of trinucleotide repeats leads to genetic

instability

7.3 General classes of DNA damage

Single base changes

Structural distortion

DNA backbone damage

Cellular response to DNA damage

7.4 Lesion bypass

7.5 Direct reversal of DNA damage

7.6 Repair of single base changes and structural distortions by

removal of DNA damage

Base excision repair

Mismatch repair

Nucleotide excision repair

Disease box 7.1 Hereditary nonpolyposis colorectal cancer: a defect

in mismatch repair

7.7 Double-strand break repair by removal of DNA damage

Homologous recombination

Nonhomologous end-joining

Disease box 7.2 Xeroderma pigmentosum and related disorders:

defects in nucleotide excision repair

Disease box 7.3 Hereditary breast cancer syndromes: mutations in

BRCA1 and BRCA2

8 Recombinant DNA technology and molecular cloning

9 Tools for analyzing gene expression

10 Transcription in prokaryotes

11 Transcription in eukaryotes

12 Epigenetic and monoallelic gene expression

13 RNA processing and post-transcriptional gene regulation

14 The mechanism of translation

15 Genetically modified organisms: use in basic and applied

research

16 Genome analysis:DNA typing,genomics and beyond

17 Medical molecular biology

Glossary

Index

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书籍介绍

《基础分子生物学(影印版)》主要内容：The beginnings of molecular biology , The structure of DNA ,Genome organization: from nucleotides to chromatin, The versatility of RNA, From gene to protein, DNA replication and telomere maintenance, DNA repair and recombination, Recombinant DNA technology and molecular cloning……。