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权威、全面、全新、全彩

举世公认的血液学经典著作

基础与实践

实验与临床

诊断与鉴别

………………

※编辑推荐※

☆经典名著 ： 《Williams血液学》是血液学领域公认的经典之作，经过多次修订，指导了一代又一代的临床医生、生物学研究者和众多学科的实习生。作者们均是各 自领域的学术带头人，他们的基础和临床成果得到了国际广泛认可。

☆内容全面 ：共139章，涵盖了血液学的所有方面。前半部分讨论了患者临床评估、血液病的分子学和细胞学基础，后半部分具体阐述了红细胞疾病、粒细胞和单核细胞疾病、淋巴细胞和浆细胞疾病、髓系肿瘤性疾病、淋巴组织疾病、止血和血栓，以及输血医学。包含彩图1300余幅。

☆与时俱进 ：《Williams血液学（第9版）》在基础科学、转换病理生理学和临床实践方面做了大篇幅的修改和更新，以反映血液学领域最新的研究进展。

☆印刷精美 ： 全书彩色印刷，包含大量极具诊断价值的细胞形态学图片，使阅读和查找更加直观、方便。

………………

※内容简介※

《Williams血液学》是血液学领域的经典之作，涵盖了血液学的所有方面，介绍了患者临床评估、血液病的分子学和细胞学基础，并具体阐述了红细胞疾病、粒细胞和单核细胞疾病、淋巴细胞和浆细胞疾病、髓系肿瘤性疾病、淋巴组织疾病、止血和血栓、输血医学等内容。

第9版在第8版的基础上做了大篇幅的修改和更新，以反映血液学领域的最新进展。新增加了表观遗传学和基因组学、血液肿瘤细胞的新陈代谢和肝素诱导性血小板减少症等内容。

本书是血液科临床医生、实习生、血液学研究人员必不可少的案头佳作，也是学习血液学专业英语的工具书。

简 目

Contributors

Preface

PART I Clinical Evaluation of the Patient

PART II The Organization of the Lymphohematopoietic Tissues

PART III Epochal Hematology

PART IV Molecular and Cellular Hematology

PART V Therapeutic Principles

PART VI The Erythrocyte

PART VII Neutrophils, Eosinophils, Basophils, and Mast Cells

PART VIII Monocytes and Macrophages

PART IX Lymphocytes and Plasma Cells

PART X Malignant Myeloid Diseases

PART XI Malignant Lymphoid Diseases

PART XII Hemostasis and Thrombosis

PART XIII Transfusion Medicine

Index

v

目 录

Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix

Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xxi

PART I

Clinical Evaluation of the Patient

1. Initial Approach to the Patient: History and Physical Examination

2. Examination of Blood Cells

3. Examination of The Marrow

4. Consultative Hematology

PART II

The Organization of the Lymphohematopoietic Tissues

5. Structure of the Marrow and the Hematopoietic Microenvironment

6. The Organization and Structure of Lymphoid Tissues

PART III

Epochal Hematology

7. Hematology of the Fetus and Newborn

8. Hematology during Pregnancy

9. Hematology in Older Persons

PART IV

Molecular and Cellular Hematology

10. Genetic Principles and Molecular Biology

11. Genomics

12. Epigenetics

13. Cytogenetics and Genetic Abnormalities

14. Metabolism of Hematologic Neoplastic Cells

15. Apoptosis Mechanisms: Relevance to the Hematopoietic System

16. Cell-Cycle Regulation and Hematologic Disorders

17. Signal Transduction Pathways

18. Hematopoietic Stem Cells, Progenitors, and Cytokines

19. The Inflammatory Response

20. Innate Immunity

21. Dendritic Cells and Adaptive Immunity

PART V

Therapeutic Principles

22. Pharmacology and Toxicity of Antineoplastic Drugs

23. Hematopoietic Cell Transplantation

24. Treatment of Infections in The Immunocompromised Host

25. Antithrombotic Therapy

26. Immune Cell Therapy

27. Vaccine Therapy

28. Therapeutic Apheresis: Indications, Efficacy, and Complications

29. Gene Therapy for Hematologic Diseases

30. Regenerative Medicine: Multipotential Cell Therapy for

Tissue Repair

PART VI

The Erythrocyte

31. Structure and Composition of the Erythrocyte

32. Erythropoiesis

33. Erythrocyte Turnover

34. Clinical Manifestations and Classification of Erythrocyte Disorders

35. Aplastic Anemia: Acquired and Inherited.

36. Pure Red Cell Aplasia

37. Anemia of Chronic Disease

38.The Congenital Dyserythropoietic Anemias

39.Paroxysmal Nocturnal Hemoglobinuria

40.Paroxysmal Nocturnal Hemoglobinuria

41.Folate, Cobalamin, and Megaloblastic Anemias

42. Iron Metabolism

43. Iron Deficiency and Overload

44.Anemia Resulting from Other Nutritional Deficiencies

45.Anemia Associated with Marrow Infiltration

46.Erythrocyte Membrane Disorders

47.Erythrocyte Enzyme Disorders

48.The Thalassemias: Disorders of Globin Synthesis

49.Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities

50.Methemoglobinemia and Other Dyshemoglobinemias

51.Fragmentation Hemolytic Anemia

52.Erythrocyte Disorders as a Result of Chemical and Physical Agents

53.Hemolytic Anemia Resulting from Infections with Microorganisms

54.Hemolytic Anemia Resulting from Immune Injury

55.Alloimmune Hemolytic Disease of the Fetus and Newborn

56.Hypersplenism and Hyposplenism

57.Primary and Secondary Erythrocytoses

58. The Porphyrias

59. Polyclonal and Hereditary Sideroblastic Anemias

PART VII

Neutrophils, Eosinophils, Basophils, and Mast Cells

60.Structure and Composition of Neutrophils,Eosinophils, and Basophils

61.Production, Distribution, and Fate of Neutrophils

62.Eosinophils and Related Disorders

63.Basophils, Mast Cells, and Related Disorders

64.Classification and Clinical Manifestations of Neutrophil Disorders

65.Neutropenia and Neutrophilia

66.Disorders of Neutrophil Function

PART VIII

Monocytes and Macrophages

67.Structure, Receptors, and Functions of Monocytes and Macrophages

68.Production, Distribution, and Activation of Monocytes and Macrophages

69.Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages

70.Monocytosis and Monocytopenia

71.Inflammatory and Malignant Histiocytosis

72.Gaucher Disease and Related Lysosomal Storage Diseases

73.PART IX

Lymphocytes and Plasma Cells

73. The Structure of Lymphocytes and Plasma Cells

74. Lymphopoiesis Functions of B Lymphocytes and Plasma Cells in Immunoglobulin Production

75.Functions of T Lymphocytes: T-Cell Receptors for Antigen

76.Functions of Natural Killer Cells

77.Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders

79. Lymphocytosis and Lymphocytopenia

80. Immunodeficiency Diseases

81. Hematologic Manifestations of Acquired Immunodeficiency Syndrome

82. Mononucleosis Syndromes

PART X

Malignant Myeloid Diseases

83. Classification and Clinical Manifestations of the Clonal Myeloid Disorders

84. Polycythemia Vera

85. Essential Thrombocythemia

86. Primary Myelofibrosis

87. Myelodysplastic Syndromes

88. Acute Myelogenous Leukemia

89. Chronic Myelogenous Leukemia and Related Disorders

PART XI

Malignant Lymphoid Diseases

90. Classification of Malignant Lymphoid Disorders

91. Acute Lymphoblastic Leukemia

92. Chronic Lymphocytic Leukemia

93. Hairy Cell Leukemia

94. Large Granular Lymphocytic Leukemia

95. General Considerations for Lymphomas: Epidemiology, Etiology, Heterogeneity, and Primary Extranodal Disease

96. Pathology of Lymphomas.

97. Hodgkin Lymphoma

98. Diffuse Large B-Cell Lymphoma and Related Diseases

99. Follicular Lymphoma

100. Mantle Cell Lymphoma

101. Marginal Zone B-Cell Lymphomas

102. Burkitt Lymphoma

103. Cutaneous T-Cell Lymphoma (Mycosis Fungoides and Sézary Syndrome)

104. Mature T-Cell and Natural Killer Cell Lymphomas

105. Plasma Cell Neoplasms: General Considerations

106. Essential Monoclonal Gammopathy

107. Myeloma.

108. Immunoglobulin Light-Chain Amyloidosis

109. Macroglobulinemia.

110. Heavy-Chain Disease

PART XII

Hemostasis and Thrombosis

111. Megakaryopoiesis and Thrombopoiesis

112. Platelet Morphology, Biochemistry, and Function

113. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis

114. Control of Coagulation Reactions

115. Vascular Function in Hemostasis

116. Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostasis

117. Thrombocytopenia

118. Heparin-Induced Thrombocytopenia

119. Reactive Thrombocytosis

120. Hereditary Qualitative Platelet Disorders

121. Acquired Qualitative Platelet Disorders

122. The Vascular Purpuras

123.Hemophilia A and Hemophilia B

124.Inherited Deficiencies of Coagulation Factors II, V,V+VIII, VII, X, XI, and XII

125.Hereditary Fibrinogen Abnormalities

126.von Willebrand Disease

127.Antibody-Mediated Coagulation Factor Deficiencies

128.Hemostatic Alterations in Liver Disease and Liver Transplantation

129.Disseminated Intravascular Coagulation

130. Hereditary Thrombophilia

131.The Antiphospholipid Syndrome

132.Thrombotic Microangiopathies

133. Venous Thrombosis

134.Atherothrombosis: Disease Initiation, Progression,and Treatment

135.Fibrinolysis and Thrombolysis

PART XIII

Transfusion Medicine

136.Erythrocyte Antigens and Antibodies

137.Human Leukocyte and Platelet Antigens

138.Blood Procurement and Red Cell Transfusion

139.Preservation and Clinical Use of Platelets

Index

考杉斯基(Kaushansky)博士是纽约州立大学石溪分校健康科学院的高级副总裁，同时担任该校医学院院长的职务。考杉斯基(Kaushansky)博士是全球知名的血液学专家，发表过多篇有影响力的著作。担任《Willians血液学》第8版、第9版的主编。

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书籍介绍

权威、全面、全新、全彩

举世公认的血液学经典著作

基础与实践

实验与临床

诊断与鉴别

………………

※编辑推荐※

☆经典名著 ： 《Williams血液学》是血液学领域公认的经典之作，经过多次修订，指导了一代又一代的临床医生、生物学研究者和众多学科的实习生。作者们均是各 自领域的学术带头人，他们的基础和临床成果得到了国际广泛认可。

☆内容全面 ：共139章，涵盖了血液学的所有方面。前半部分讨论了患者临床评估、血液病的分子学和细胞学基础，后半部分具体阐述了红细胞疾病、粒细胞和单核细胞疾病、淋巴细胞和浆细胞疾病、髓系肿瘤性疾病、淋巴组织疾病、止血和血栓，以及输血医学。包含彩图1300余幅。

☆与时俱进 ：《Williams血液学（第9版）》在基础科学、转换病理生理学和临床实践方面做了大篇幅的修改和更新，以反映血液学领域最新的研究进展。

☆印刷精美 ： 全书彩色印刷，包含大量极具诊断价值的细胞形态学图片，使阅读和查找更加直观、方便。

………………

※内容简介※

《Williams血液学》是血液学领域的经典之作，涵盖了血液学的所有方面，介绍了患者临床评估、血液病的分子学和细胞学基础，并具体阐述了红细胞疾病、粒细胞和单核细胞疾病、淋巴细胞和浆细胞疾病、髓系肿瘤性疾病、淋巴组织疾病、止血和血栓、输血医学等内容。

第9版在第8版的基础上做了大篇幅的修改和更新，以反映血液学领域的最新进展。新增加了表观遗传学和基因组学、血液肿瘤细胞的新陈代谢和肝素诱导性血小板减少症等内容。

本书是血液科临床医生、实习生、血液学研究人员必不可少的案头佳作，也是学习血液学专业英语的工具书。