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This book presents a selection of revised full papers accepted for presentation at the First International Conference on Biology, Informatics, and Mathematics, JOBIM 2000, held in Montpellier, France, in May 2000.The 13 papers included in the book were selected after two rounds of reviewing and revision from a total of 67 submissions. Among the topics addressed are algorithms, comparative genomics, evolution, phylogeny, databases, knowledge processing, genome anotation, graph theory, combinatorial mathematics, macromolecular structures, RNA and proteins, metabolic pathways and regulatory networks, and statistics and classification

Speeding Up the DIALIGN Multiple Alignment Program by Using the 'Greedy Alignment of BIOlogical Sequences LIBrary' (GABIOS-LIB)

GeMCore, a Knowledge Base Dedicated to Mapping Mammalian Genomes

Optimal Agreement Supertrees

Segmentation by Maximal Predictive Partitioning According to Composition Biases

Can We Have Confidence in a Tree Representation?

Bayesian Approach to DNA Segmentation into Regions with Different Average Nucleotide Composition

Exact and Asymptotic Distribution of the Local Score of One i.i.d. Random Sequence

Phylogenetic Reconstruction Algorithms Based on Weighted 4-Trees

Computational Complexity of Word Counting

EUGENE: An Eukaryotic Gene Finder That Combines Several Sources of Evidence

Tree Reconstruction via a Closure Operation on Partial Splits

InterDB, a Prediction-Oriented for C. elegans

Protein Interaction Database

Application of Regulatory Sequence Analysis and Metabolic Network Analysis to the Interpretation of Gene Exprtession Data

Author Index

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The LNCS series reports state-of-the-art results in computer science research，development，and education，at a high level and in both printed and electronic form.Enjoying tight cooperation with the R&D community，with numerous individuals，as well as with prestigious organizations and societies，LNCS has grown into the most comprehensive computer science research forum available.

The scope of LNCS including its subseries LNAI spans the whole range of computer science and information technology including interdisciplinary topics in a variety of application fields.The type of material published traditionally includes.

—proceedings （published in time for the respective conference）

—post-proceedings （consisting of thoroughly revised final full papers）

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This book presents a selection of revised full papers accepted for presentation at the First International Conference on Biology, Informatics, and Mathematics, JOBIM 2000, held in Montpellier, France, in May 2000.The 13 papers included in the book were selected after two rounds of reviewing and revision from a total of 67 submissions. Among the topics addressed are algorithms, comparative genomics, evolution, phylogeny, databases, knowledge processing, genome anotation, graph theory, combinatorial mathematics, macromolecular structures, RNA and proteins, metabolic pathways and regulatory networks, and statistics and classification.