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简? 目

Contributorr>Preface

PART IClinical Evaluation

of the Patient

PARTII? TheOrganization of the LymphohematopoieticTissuer>PARTIII?

EpochalHematology

PARTIV?

Molecular and CellularHematology

PARTV? TherapeuticPrincipler>PARTVI? The Erythrocyte

PARTVII? Neutrophils,Eosinophils,Basophils, and Mar>Cellr>PARTVIII?

Monocytes and Macrophager>PARTIX? Lymphocytes and Plasma Cellr>PARTX? MalignantMyeloid Diseaser>PARTXI? MalignantLymphoid Diseaser>PARTXII? Hemostasis andThrombosir>PARTXIII? Transfusion Medicine

Index

?

?

?

v?

?

?

目? 录

Contributors. . . . .

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

. .ix

Preface. . . . .

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

. . . . . .xxi

?

PART I

ClinicalEvaluation of the Patient

1.InitialApproachto the Patient:HistoryandPhysicalExamination

2.Examinationof Blood Cellr>3.ExaminationofTheMarrow

4.ConsultativeHematology

PART II

TheOrganization of the LymphohematopoieticTissue>

5.Structureof the Marrowand the HematopoieticMicroenvironment

6.The Organization

and StructureofLymphoid

Tissuer>PART III

Epochal Hematology

7.Hematologyof the FetusandNewborn

8.HematologyduringPregnancy

9.Hematology in OlderPersonr>?

PART IV

Molecular and CellularHematology

10.Geic PrinciplesandMolecular Biology

11.Genomicr>12.Epigeicr>13.Cytogeicsand Geic Abnormalitier>14.MetabolismofHematologicNeoplastic Cellr>15.ApoptosisMechanisms:Relevanceto the HematopoieticSystem

16.Cell-CycleRegulationandHematologicDisorderr>17.SignalTransductionPathwayr>18.HematopoieticStem Cells, Progenitors,andCytokiner>19.TheInflammatory

Responr>.InnateImmunity

21.Dendritic Cells andAdaptiveImmunity

PARTV

TherapeuticPrinciple>

22.PharmacologyandToxicityofAntineoplastic Drugr>23.Hematopoietic Cell Transplantation

24.Treatment of InfectionsinTheImmunocompromisedHor>25.AntithromboticTherapy

26.Immune Cell Therapy

27.VaccineTherapy

28.TherapeuticApheresis:Indications,Efficacy,andComplicationr>29.Gene TherapyforHematologicDiseaser>30.RegenerativeMedicine:MultipotentialCellTherapy for

TissueRepair

PARTVI

The Erythrocyte

31.StructureandCompositionof the Erythrocyte

32.Erythropoiesir>33.Erythrocyte Turnover

34.ClinicalManifestations and Classification ofErythrocyteDisorderr>35.AplasticAnemia:Acquiredand Inherited.

36. Pure Red Cell Aplasia

37.? Anemia of

ChronicDisear>38.?

The Congenital

DyserythropoieticAnemiar>39.? Paroxysmal

Nocturnal Hemoglobinuria

40.? ParoxysmalNocturnalHemoglobinuria

41.? Folate,Cobalamin,andMegaloblasticAnemiar>42.IronMetabolir>43.Iron Deficiency andOverload

44.? Anemia

Resulting fromOtherNutritionalDeficiencier>45.? Anemia

AssociatedwithMarrowInfiltration

46.? Erythrocyte MembraneDisorderr>47.? Erythrocyte Enzyme Disorderr>48.? TheThalassemiar>Disorders of GlobinSynthesir>49.? DisordersofHemoglobinStructure:Sickle CellAnemiaandRelatedAbnormalitier>50.? Methemoglobinemiaand Other Dyshemoglobinemiar>51.? FragmentationHemolyticAnemia

52.? Erythrocyte Disordersas a ResultofChemicalandPhysicalAgentr>53.? HemolyticAnemiaResultingfromInfectionswithMicroorganismr>54.? HemolyticAnemiaResultingfromImmuneInjury

55.? AlloimmuneHemolytic Disease of the FetusandNewborn

56.? HypersplenismandHyposplenir>57.? Primary and Secondary Erythrocytoser>58.ThePorphyriar>59.PolyclonalandHereditarySideroblasticAnemiar>PARTVII

Neutrophils,Eosinophils,Basophils, and Mast Cell>

60. StructureandCompositionofNeutrophils,Eosinophils,andBasophilr>61. Production,Distribution,andFateofNeutrophilr>62. EosinophilsandRelatedDisorderr>63. Basophils,Mast Cells, andRelatedDisorderr>64. Classificationand

Clinical ManifestationsofNeutrophilDisorderr>65. NeutropeniaandNeutrophilia

66. DisordersofNeutrophilFunction

PARTVIII

Monocytes and Macrophage>

67. Structure,Receptors,andFunctionsofMonocytesandMacrophager>68. Production,Distribution,andActivationofMonocytesandMacrophager>69. Classificationand

ClinicalManifestationsof DisordersofMonocytesandMacrophager>70. MonocytosisandMonocytopenia

71. Inflammatory

andMalignantHistiocytosir>72.? Gaucher Disease andRelatedLysosomalStorageDiseaser>73.? PART IX

Lymphocyte> and Plasma Cell>

73.The

StructureofLymphocytes andPlasma Cellr>74.LymphopoiesisFunctionsof B LymphocytesandPlasma

Cells inImmunoglobulinProduction

75.? Functionsof T Lymphocytes:T-CellReceptorsforAntigen

76.? FunctionsofNaturalKiller Cellr>77.? Classificationand

Clinical ManifestationsofLymphocyteandPlasma Cell Disorderr>79.LymphocytosisandLymphocytopenia

80.Immunodeficiency

Diseaser>81.HematologicManifestationsofAcquiredImmunodeficiencySyndrome

82.MononucleosisSyndromer>PART X

MalignantMyeloid Disease>

83.Classification

and ClinicalManifestationsoftheClonalMyeloidDisorderr>84.PolycythemiaVera

85.EssentialThrombocythemia

86.Primary Myelofibrosir>87.MyelodysplasticSyndromer>88.AcuteMyelogenousLeukemia

89.ChronicMyelogenousLeukemiaandRelatedDisorderr>PART XI

MalignantLymphoid Disease>

90.ClassificationofMalignantLymphoid Disorderr>91.AcuteLymphoblasticLeukemia

92.ChronicLymphocyticLeukemia

93.Hairy Cell Leukemia

94.LargeGranularLymphocyticLeukemia

95.General ConsiderationsforLymphomas:Epidemiology,Etiology,Heterogeneity,and Primary Extranodal

Disear>96.PathologyofLymphomar>97.HodgkinLymphoma

98.Diffuse Large B-Cell Lymphoma andRelated Diseaser>99.FollicularLymphoma

100.Mantle Cell Lymphoma

101.MarginalZone B-Cell Lymphomar>102.BurkittLymphoma

103.CutaneousT-CellLymphoma(MycosisFungoidesandSézarySyndrome)

104.MatureT-CellandNaturalKiller Cell Lymphomar>105.Plasma Cell Neoplasmr>General Considerationr>106.EssentialMonoclonalGammopathy

107.Myeloma.

108.ImmunoglobulinLight-ChainAmyloidosir>109.Macroglobulinemia.

110.Heavy-Chain Disear>PART XII

Hemostasi> andThrombosi>

111.Megakaryopoiesir>andThrombopoiesir>112.PltMorphology,Biochemistry,and Function

113.Molecular Biology andBiochemistryof theCoagulationFactorsandPathwaysofHemostasir>114.ControlofCoagulationReactionr>115.VascularFunction in Hemostasir>116.Classification,

Clinical Manifestations, andEvaluationofDisordersofHemostasir>117.Thrombocytopenia

118.Heparin-Induced

Thrombocytopenia

119.ReactiveThrombocytosir>1.HereditaryQualitativePltDisorderr>121.AcquiredQualitativePltDisorderr>122.TheVascularPurpurar>123. Hemophilia A andHemophilia B

124. InheritedDeficiencies of

Coagulation FactorsII,V,V VIII, VII, X, XI, and XII

125.

Hereditary Fibrinogen

Abnormalitier>126.

von Willebrand

Disear>127. Antibody-Mediated

Coagulation FactorDeficiencier>128. HemostaticAlterations in Liver Disease andLiverTransplantation

129. DisseminatedIntravascularCoagulation

130.HereditaryThrombophilia

131. The AntiphospholipidSyndrome

132. Thrombotic

Microangiopathier>133.VenousThrombosir>134. Atherothrombosis: Disease Initiation,Progression,andTreatment

135. Fibrinolysir>andThrombolysir>PART XIII

Transfusion Medicine

136. Erythrocyte AntigensandAntibodier>137. Human Leukocyte andPltAntigenr>138. Blood Procurementand Red Cell Transfusion

139. Preservationand Clinical UseofPltr>Index

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编辑推荐

经典名著; 《Williams血液学》是血液学领域的经典之作，经过多次修订，指导了一代又一代的临床医生、生物学研究者和众多学科的实作者们均是各自领域的学术带头人，他们的基础和临床成果得到了广泛认可。

内容; 共139章，涵盖了血液学的所有方面。前半部分讨论了患者临床评估、血液病的分子学和细胞学基础，后半部分具体阐述了红细胞疾病、粒细胞和单核细胞疾病、淋巴细胞和浆细胞疾病、髓系疾病、淋巴组织疾病、止血和血栓，以及输血医学含彩图1300余幅。

与时; 《Williams血液学（第9版）》在基础科学、转换病理生理学和临床实践方面做了大篇幅的修改和更新，以反映血液学领域*的研展。

印刷精美;; 全书彩色印刷含大量诊断价值的细胞形态学图片，使阅读和查找更加直观、方便。

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