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From Antarctica to Zimbabwe, if you're going there, chances are Lonely Planet has been there first. With a pithy and matter-of-fact writing style, these guides are guaranteed to calm the nerves of first-time world travelers, while still listing off-the-beaten-path finds sure to thrill even the most jaded globetrotters. Lonely Planet has been perfecting its guidebooks for nearly 30 years and as a result, has the experience and know-how similar to an older sibling's "been there" advice. The original backpacker's bible, the LP series has recently widened its reach. While still giving insights for the low-budget traveler, the books now list a wide range of accommodations and itineraries for those with less time than money.

The Authors

GettingStarted

Itineraries

The Culture

Environment

Italian Artistic

Tradition

Food & Drink

Rome & Lazio　

　ROME

　　History

　　Orientation

　　Information

　　Dangers & Annoyances

　　Sights

　 Walking Tour

　 Courses

　 Rome for Children

　 Tours

　 Festivals & Events

　 Sleeping

　 Eating

　 Drinking

　 Entertainment

　　Shopping

　　Getting There & Away

　　Getting Around

　LAZlO

　　Ostia Antica

　　Tivoli

　　Etruscan Sites

　　Civitavecchia

　　Viterbo

　　Around Viterbo

　　The Lakes

　　Castelli Romani

　　Palestrina

　　Anagni & Alatri

　　Along the Coast

　　Isole Pontine

Liguria, Piedmont & Valle d'Aosta

　LIGURIA

　　Genoa

　　Around Genoa

　　Riviera di Levante

　　Riviera di Ponente

　PIEDMONT

　　Turin

　　Valle di Susa & Valle di Chisone

　　Southern Piedmont

　　Eastern & Northern

　　Piedmont

　VALLE D'AOSTA

　　Aosta

　　Aosta Valley Castles

　　Courmayeur

　　Parco Nazionale　del Gran Paradiso

　　Valtournenche

　　Valle d'Ayas, Val di

　　Gressoney & Valsesia

Lombardy& tha Lakes

　MILAN

　　History

　　Orientation

　　Information

　　Dangers & Annoyances

　　Sights

　　Tours

　　Festivals & Events

　　Sleeping

　　Eating

　　Drinking

　　Entertainment

　　Shopping

　　Getting There & Away

　　Getting Around

　SOUTH OF MILAN

　　Pavia

　EAST OF MILAN

　　Bergamo

　　Valtellina

　　Brescia

　　Cremona

　　Mantua

……

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为了让小鼠长出前列腺肿瘤，必须把包含有前列腺特异基因启动子和SV40—T基因的杂合基因插入一个小鼠的受精卵。如果插入成功，就会得到一只转基因小鼠，这样，成长的小鼠就能在其前列腺中表达外来的基因了。可以预测，这些小鼠会继续长出多个前列腺肿瘤。人们培育了一些这种易患癌症的小鼠，该品系被称作“小鼠前列腺转基因腺癌”（TRAMP）模型。事实证明，这些小鼠有多种用途。首先，因为小鼠一定能长出肿瘤，它们可被用于检验诸如饮食干预等预防癌症的策略。其次，它们的肿瘤可以用于测试药物治疗的有效性。最后，来自TRAMP小鼠的肿瘤细胞已经在实验室成功地培养出来，这些细胞系可以供试验使用：既可单独使用，也可被重新移植进同一小鼠品系的成年动物体内——这比等待TRAMP小鼠本身长出肿瘤来要快得多，可复制性也更强。

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